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29) Leveraging Pyrazolium Ylide Reactivity to Access Indolizine and 1,2-Dihydropyrimidine Derivatives

Tran, R.; Brownsey, D. K.; O'Sullivan, L.; Brandow, C. M. J.; Chang, E. S.; Zhou, W.; Patel, K. V.; Gorobets, E.; Derksen, D. J. Chem. Eur. J. 2024, 59, accepted for publication


28) Utilising the intrinsic fluorescence of pomalidomide for imaging applications

Brownsey, D. K.; Gafuik, C. J.; Kim, D.-S.; O'Sullivan, L.; Gorobets, E.; Krukowski, S.; Turk, M.; Jenne, C. N.; Mahoney, D. J.; Derksen, D. J. Chem. Commun. 2023, 59, 14532-14545.

This article is part of the 2023 Pioneering Investigators themed collection

27) macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma

Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo. Nat. Commun. 2023, 14, 3062.


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Papatzimas, J. W.; Gorobets, E.; Maity, R.; Muniyat, M. I.; MacCallum, J. L.; Neri, P.; Bahlis, N. J.*; Derksen, D. J.*  J. Med. Chem. 2019, 62, 11, 5522-5540.

doi: 10.1021/acs.jmedchem.9b00455

19) From Inhibition to Degradation: Targeting the Anti-Apoptotic Protein Myeloid Cell Leukemia 1 (MCL1)

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 - Highlighted in Cancer Discovery, News in Depth Article 


 Targeting MCL1, Companies Aim to Unblock Apoptosis by Elie Dolgin, PhD

              doi: 10.1158/2159-8290.CD-ND2019-002



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18) Beyond Geminal Diesters: Increasing the Scope of Metal-Mediated Vinylcyclopropane Annulations while Decreasing Pre-activation

Brownsey, D. K.; Gorobets, E.; Derksen, D. J.* Org. Biomol. Chem. 2018, 16, 3506-3523.

doi:  10.1039/C8OB00593A


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17) Structure-Activity Relationship (SAR) Studies of Transient Receptor Potential (TRP) Channel Modulators

LeGay, C. M.;Derksen, D. J.* In 2017 Medicinal Chemistry Reviews; Bronson, J. J., Ed.; Medicinal Chemistry Division of the American Chemical Society: Washington, DC, 2017; Vol. 52; pp. 443-463. 

16) General Strategy for the Preparation of Thalidomide-Conjugate Linkers

Papatzimas, J. W.; Gorobets, E.; Brownsey, D. K.; Maity, R.; Bahlis, N. J.; Derksen, D. J.*SynLett 2017, 28, 2881-2885.  Invited manuscript for special issue dedicated to Professor Victor Snieckus.

doi: 10.1055/s-0036-1588539

15) Divergent Photocyclization/1,4-Sigmatropic Rearrangements for the Synthesis of Sesquiterpenoid Derivatives

Gorobets, E.; Wong, N. E.; Paton, R. S.; Derksen, D. J.* Org. Lett. 2017, 19, 484-487.

doi: 10.1021/acs.orglett.6b03635

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14) Thiaporphyrin-mediated Photocatalysis Using Red Light

Lee, J.; Papatzimas, J. W.; Bromby, A. D.; Gorobets, E.; Derksen, D. J.*  RSC Adv. 2016, 6, 59269-59272.

doi: 10.1039/c6ra11374e

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13) Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators

LeGay, C. M.; Gorobets, E.; Iftinca, M.; Ramachandran, R.; Altier, C.; Derksen, D. J.* Org. Lett. 2016, 18, 2746-2749.

doi: 10.1021/acs.orglett.6b01222

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12) Generation of Benzyne Species from Diphenylphosphoryl Derivatives - Simultaneous Exchange of Three Functional Groups

 Gorobets, E.; Parvez, M.; Derksen, D. J.; Keay, B. A.* Chem. Eur. J. 2016, 22, 8479-8482.

doi: 10.1002/chem.201601370

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11) Synthesis and Evaluation of Anti-inflammatory Activity of Derivatives of the Marine Natural Products Fuscol and Eunicol

Kerr, R. G.*; Brophy, S.; Derksen, D. J.* Bioorg. Med. Chem. Lett. 2014, 24, 4804-4806.

doi: 10.1016/j.bmcl.2014.09.008

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10) Inhibition of Serine and Proline Racemases by Substrate-Product Analogues

Harty, M.; Nagar, M.; Atkinson, L.; LeGay, C. M.; Derksen, D. J.* Bearne, S. L.*Bioorg. Med. Chem. Lett. 2014, 24, 390-393.

doi: 10.1016/j.bmcl.2013.10.061

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9) Interactions of Protamine with the Marine Bacterium, Pseudoalteromonas sp. 

Pustam, A.; Smith, C.; Deering, C.; Grosicki, K.; Leng, T.-Y.; Yang, J.; Lin, S.; Pink, D.; Gill, T.; Graham, L.; Derksen, D.; Bishop, C.; Demont, M.; Wyeth, R.; Smith-Palmer, T.* NCIMB 2021. Lett. Appl. Microbiol. 2013, 58, 225-230.

doi: 10.1111/lam.12177


8) Elucidating Absolute Configuration of Unsaturated Alcohols via Enantioselective Acylation Reactions

LeGay, C. M.; Boudreau, C. G.; Derksen, D. J.* Org. Biomol. Chem. 2013, 11, 3432-3435.

doi: 10.1039/C3OB40709H 

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7) Preparation and Use of Cysteine Orthoesters for Solid-Supported Synthesis of Peptides

Huang, Z.; Derksen, D. J.; Vederas, J. C. Org. Lett. 2010, 12, 2282-2285.

doi: 10.1021/ol100645t 

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6) The Role of Hydrophobic Interactions in the N-terminus of Leucocin A and Pediocin PA-1

 Derksen, D. J.; Boudreau, M. A.; Vederas, J. C. Chembiochem, 2008, 9, 1898-1901.

doi: 10.1002/cbic.200800272



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20) Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook

Navis, Kathleen E.; Fan, Churmy Y.; Trang, Tuan.;Thompson, Roger J.;Derksen, Darren J.* ACS Chemical Neuroscience. 2020, 11, 15, 2163–2172.

21) ADAM Protease Inhibition Overcomes Resistance of Breast Cancer Stem-Like Cell to gamma, delta T Cell Immunotherapy

Dutta, I.; Dieters-Castator, D.; Papatzimas, J. W.; Medina, A.; Derksen, D. J.; Lajoie, G.; Postovit, L.-M. Siegers, G. M.* Cancer Lett. 2021, 496, 156-168.

22) Rapid Synthesis of Pomalidomide-Conjugates for the Development of Protein Degrader Libraries

Brownsey, D. K.; Rowley, B. C.; Gorobets, E.; Gelfand, B. S.; Derksen, D. J.* Chem. Sci. 2021, 12, 4519-4525.

23) Metformin prevents hyperglycaemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor, Nr4a1 (Nur77)

Pulakazhi Venu V. K.; Saifeddine, M; Mihara, K:, Faiza, M;, Gorobets, E; Flewelling, A. J.; Derksen, D. J.; Hirota, S.; Marei, I.; Al-Majid, D.; Motahhary, M.; Ding, H.; Triggle, C. R.; Hollenberg, M. D. Mol. Pharmacol. 2021, 100, 428-455.


24) Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles

O'Sullivan, L.; Patel, K. V.; Rowley, B. C.; Brownsey, D. K.; Gorobets, E.; Gelfand, B. S.; Van Humbeck, J. F.; Derksen, D. J.* J. Org. Chem. 2022, 87, 846-854.



25) A Vinylogous Norrish Reaction as a Strategy for Light-Mediated Ring Expansion

Gorobets, E.; Papatzimas, J. W.; Dourado, J.; Yousefalizadeh, G.; Lee, J.; Brownsey, D. K. Stamplecoskie, K.* Davis, R. ;* Derksen, D. J.* Chem. Commun. 2022, 58, 2910-2913.


26) Identification of ligand linkage vectors for the development of p300/CBP degraders

Brownsey, D. K.; Rowley, B. C.; Gorobets, E.; Mihara, K.; Maity, R.; Papatzimas, J. W.; Gelfand, B. S.; Hollenberg, M. D.; Bahlis, N. J.; Derksen, D. J.* RSC Med. Chem. 2022, 13, 726-730.

This article is part of the Emerging Investigators themed collection.

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5) Structure Function Relationship of Inducer Peptide Pheromones Involved in Bacteriocin Production in Carnobacterium maltaromaticum and Enterococcus faecium

Van Belkum, M. J.; Derksen, D. J.; Franz, C. M. A. P.; Vederas, J. C. Microbiology, 2007, 153, 3660-3666.

doi: 10.1099/mic.0.2007/009183-0

4) Multiple On-Resin Olefin Metathesis to Form Ring Expanded Analogues of the Lantibiotic Peptide, Lacticin 3147 A2

Pattabiraman, V. R.; Stymiest, J. L.; Derksen, D. J.; Martin, N. I.; Vederas, J. C. Org. Lett. 2007, 9, 699-702. 

doi: 10.1021/ol063133j  

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3) Antimicrobial Leucocin Analogues with a Disulfide Bridge Replaced by a Carbocycle or by Noncovalent Interactions of Allyl Glycine Residues

Derksen, D. J.; Stymiest, J. L.; Vederas, J. C. J. Am. Chem. Soc. 2006, 128, 14252-14253.

doi: 10.1021/ja066203q

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2) Production of Piscicolin 126 by Carnobacterium maltaromaticum UAL26 is Controlled by Temperature and Induction Peptide Concentration

Gursky, L. J.; Martin, N. I.; Derksen, D. J.; van Belkum, M. J.; Kaur, K.; Vederas, J. C.; Stiles, M. E.; McMullen, L. M. Arch. Microbiol. 2006, 186, 317-325.

doi: 10.1007/s00203-006-0147-z


1) Photolysis of Diacyl Peroxides: A Radical Based Approach for the Synthesis of Functionalized Amino Acids

Spantulescu, M. D.; Jain, R. P.; Derksen, D. J.; Vederas, J. C.  Org. Lett. 2003, 5, 2963-2965. 

doi: 10.1021/ol035125y

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